Biological Networks – System Level Design

Biological Networks

It is well established that bacteria engage in social behavior and form networked communities via molecular signaling. We analyze the network dynamics and biofilm metrics, showing that our method can effectively reveal the underlying intercellular communication process and community organization within the biofilm. We claim that the application of social and network sciences to understanding bacteria population dynamics can aid in developing better drugs to control the many pathogenic bacteria that use social interactions to cause infections.

biological networks

Selected Publications

19 entries « ‹ 1 of 4 › »

Lo, Chieh; Marculescu, Radu

MetaNN: accurate classification of host phenotypes from metagenomic data using neural networks Journal Article

In: Bmc Bioinformatics, vol. 20, no. 12, pp. 314, 2019.

Lo, Chieh; Marculescu, Radu

PGLasso: Microbial Community Detection through Phylogenetic Graphical Lasso Journal Article

In: arXiv preprint arXiv:1807.08039, 2018.

Lo, Chieh; Bhardwaj, Kartikeya; Marculescu, Radu

Towards cell-based therapeutics: A bio-inspired autonomous drug delivery system Journal Article

In: Nano communication networks, vol. 12, pp. 25–33, 2017.

Koorehdavoudi, Hana; Bogdan, Paul; Wei, Guopeng; Marculescu, Radu; Zhuang, Jiang; Carlsen, Rika Wright; Sitti, Metin

Multi-fractal characterization of bacterial swimming dynamics: a case study on real and simulated serratia marcescens Journal Article

In: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 473, no. 2203, pp. 20170154, 2017.

Lo, Chieh; Marculescu, Radu

Inferring microbial interactions from metagenomic time-series using prior biological knowledge Proceedings Article

In: Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics, pp. 168–177, 2017.

Shah, Sohil; Raghavachari, Ashwin; Lo, Chieh; Marculescu, Radu

Molecular communication with DNA cellular storage system Proceedings Article

In: Proceedings of the 4th ACM International Conference on Nanoscale Computing and Communication, pp. 1–6, 2017.

19 entries « ‹ 1 of 4 › »