Biological Networks

It is well established that bacteria engage in social behavior and form networked communities via molecular signaling. We analyze the network dynamics and biofilm metrics, showing that our method can effectively reveal the underlying intercellular communication process and community organization within the biofilm. We claim that the application of social and network sciences to understanding bacteria population dynamics can aid in developing better drugs to control the many pathogenic bacteria that use social interactions to cause infections.

biological networks

Selected Publications

19 entries « 2 of 4 »

Lo, Chieh; Marculescu, Radu

MPLasso: Inferring microbial association networks using prior microbial knowledge Journal Article

In: PLoS computational biology, 13 (12), pp. e1005915, 2017.

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Lo, Chieh; Marculescu, Radu

Autonomous and adaptive control of populations of bacteria through environment regulation Inproceedings

In: International Conference on Computational Methods in Systems Biology, pp. 168–185, Springer, Cham 2016.

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Lo, Chieh; Bhardwaj, Kartikeya; Marculescu, Radu

An autonomous and adaptive bacteria-based drug delivery system Inproceedings

In: Proceedings of the 3rd ACM International Conference on Nanoscale Computing and Communication, pp. 1–6, 2016.

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Wei, Guopeng; Lo, Chieh; Walsh, Connor; Hiller, Luisa N; Marculescu, Radu

In Silico Evaluation of the Impacts of Quorum Sensing Inhibition (QSI) on strain competition and development of QSI resistance Journal Article

In: Scientific reports, 6 , pp. 35136, 2016.

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Wei, Guopeng; Walsh, Connor; Cazan, Irina; Marculescu, Radu

Molecular tweeting: unveiling the social network behind heterogeneous bacteria populations Inproceedings

In: Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics, pp. 366–375, 2015.

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Lo, Chieh; Wei, Guopeng; Marculescu, Radu

Towards autonomous control of molecular communication in populations of bacteria Inproceedings

In: Proceedings of the Second Annual International Conference on Nanoscale Computing and Communication, pp. 1–6, 2015.

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19 entries « 2 of 4 »